Dextromethorphan produces a range of toxicities depending upon either the dose or the components of the specific formulation that was ingested. It has multiple mechanisms of action, including actions as a nonselective serotonin reuptake inhibitor and a sigma1 receptor agonist. Dextromethorphan hydrobromide drug information, professional. Its mechanism of action is as an nmda receptor antagonist, producing effects similar to those of ketamine and phencyclidine pcp. Who expert committee on drug dependence, seventeenth report pdf. Dextromethorphan is an uncompetitive nmethyldaspartate receptor antagonist and sigma1 agonist. Cough treatmentdextromethorphan is indicated for the temporary symptomatic relief of nonproductive cough due to minor throat and bronchial irritation occurring with colds or inhaled irritants. Combination dextromethorphan quinidine nuedexta has fda approval for pseudobulbar affect.
Antiviral drugs introduction and mechanism pharmacology by dr rajesh gubba duration. There is animal evidence indicating that at least some of dextromethorphans antidepressant actions involve sigma1 receptors 57. By reducing the bodys reflex to cough, dextromethorphan can help to treat coughing due to a cold or flu. Possible sites of action of peripherallyor centrallyactive antitussive drugs. One candidate for this is dextromethorphan, and here the pharmacologic mechanism. Depicted is a model of the types of peripheral afferents that contribute to, or modify, the production of cough and their influence on the central components of the cough reflex. Start a free trial of quizlet plus by thanksgiving lock in 50% off all year try it free. Mechanism of action dextromethorphan hydrobromide is a semisynthetic derivative of opium that acts centrally to elevate the cough threshold. It does not have addictive, analgesic or sedative action and in usual doses does not produce respiratory depression or inhibit ciliary activity. Bhanu prakash usmle, fmge and neet pg recommended for you. Learn vocabulary, terms, and more with flashcards, games, and other study tools.